Association of interleukin-6 circulating levels with coronary artery disease: A meta-analysis implementing mendelian randomization approach

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• 作者：Wenquan Niu^a ; ¹ ; ^{niuwenquan@yahoo.cn} ; Yan Liu^b ; ; Yue Qi^c ; ; Zhijun Wu^b ; Dingliang Zhu^a ; Wei Jin^b ; ^{jinwei_ivy@126.com}
• 关键词：Coronary artery disease ; Interleukin 6 ; Polymorphism ; Meta-analysis ; Mendelian randomization
• 刊名：International Journal of Cardiology
• 出版年：2012
• 期刊代码：128_01675273
• 类别：med
• 出版时间：31 May, 2012
• 卷：157
• 期：2
• 页码：243-252
• 文件大小：902 K

摘要

Background

We aim to investigate whether the association between circulating interleukin 6 (IL-6) levels and the risk for coronary artery disease (CAD) is robust and perhaps even causal by a meta-analysis implementing mendelian randomization approach with IL-6 gene G-174C polymorphism as an instrument.

Methods

Data were available from 19 articles encompassing 9417 CAD patients and 15982 controls. A random effects model was applied irrespectively of between-study heterogeneity, and publication bias was examined using a funnel plot and the corresponding statistics.

Results

Overall, comparison of IL-6 gene alleles -174C with -174G had 4%increased risk for CAD (95%confidence interval [95%CI]: 0.97-1.10; P = 0.285), accompanying marginal heterogeneity (I² = 38.3%; P = 0.033). This association was potentiated in dominant model as odds ratio (OR) reached 1.08 (95%CI: 0.96-1.22; P = 0.204) and heterogeneity was significant (I² = 58.4%; P < 0.0005). Subgroup analysis by ethnicity indicated that carriers of -174C allele were associated with a 12%increased risk for CAD in prospective studies involving White populations (OR = 1.12; 95%CI: 0.95-1.33; P = 0.184), whereas the association in East Asians was remarkably reversed with 37-46%reduced risk. Relative to -174GG homozygotes, carriers of -174C allele had an overall 0.24 pg/ml high circulating IL-6 levels (P = 0.047). The predicted OR for 1 pg/ml elevation in IL-6 levels was 1.60 (95%CI: 1.44-1.72; P < 0.01) in prospective studies involving White populations. Publication biases were absent for all comparisons (P > 0.1).

Conclusion

Our findings provided strong evidence on the causal association of circulating IL-6 levels with the development of CAD in White populations.