Pre-treatment with an intravenous lipid emulsion containing fish oil (eicosapentaenoic and docosahexaenoic acid) decreases inflammatory markers after open-heart surgery in infants: A randomized, controlled trial

详细信息	查看全文 | 推荐本文 |

• 作者：Bodil M.K. Larsen^a ; ^b ; ^c ; ^{bodil.larsen@albertahealthservices.ca} ; Laksiri A. Goonewardene^d ; ^e ; ^{laki.goonewardene@ualberta.ca} ; Ari R. Joffe^f ; ^g ; ^{ajoffe@ualberta.ca} ; John E. Van Aerde^f ; ^g ; ^{jvanaerd@ualberta.ca} ; Catherine J. Field^b ; ^c ; ^d ; ^{catherine.field@ualberta.ca} ; Dana Lee Olstad^b ; ^d ; ^{dana.olstad@ualberta.ca} ; Michael T. Clandinin^b ; ^c ; ^d ; ^{tclandin@professorpufa.com}
• 关键词：Docosahexaenoic acids ; Eicosapentaenoic acid ; Fat emulsions ; Intravenous ; Inflammation ; Critical care ; Randomized controlled trial
• 刊名：Clinical Nutrition
• 出版年：2012
• 期刊代码：52_02615614
• 类别：med
• 出版时间：June, 2012
• 卷：31
• 期：3
• 页码：322-329
• 文件大小：272 K

摘要

| Figures/TablesFigures/Tables | ReferencesReferences

Summary

Background & aims

This study assessed the effects of administering a lipid emulsion containing eicosapentaenoic and docosahexaenoic acid before and after open-heart surgery on cytokine production and length of hospital stay in infants.

Methods

Thirty-two infants (40聽卤聽2.3 weeks gestational age; 10.6 days at time of surgery) undergoing open-heart surgery with cardiopulmonary bypass were randomized to receive an intravenous lipid emulsion with (treatment) or without (control) eicosapentaenoic and docosahexaenoic acid in this prospective, randomized, double-blind, controlled trial.

Results

Mean plasma TNF-伪 concentration was significantly (p聽=聽0.003) lower in the treatment (5.9聽pg/mL) compared to the control group (14.8聽pg/mL). In infants without sepsis, plasma TNF-伪 did not differ according to treatment, however when sepsis developed, mean plasma TNF-伪 was 21.1聽pg/mL and 1.5聽pg/mL (p聽=聽0.0007) in control and treatment groups, respectively. Plasma TNF-伪 was positively correlated with length of hospital stay in the control group (p聽=聽0.01), and negatively correlated with length of stay in the treatment group (p聽=聽0.004), with a significant time by treatment interaction (p聽=聽0.02).

Conclusions

Providing a lipid emulsion containing eicosapentaenoic and docosahexaenoic acid reduces TNF-伪 concentrations in infants undergoing open-heart surgery. Lipid emulsions containing eicosapentaenoic and docosahexaenoic acid may ameliorate the inflammatory response among critically ill infants.

This trial was registered at as NCT00336908.