Neurofascin: A switch between neuronal plasticity and stability
- 作者：Martin Kriebel ; Jennifer Wuchter ; Sabine Trinks ; Hansjü ; rgen Volkmer ; volkmer@nmi.de
- 关键词：AIS ; axon initial segment ; CHL1 ; close homologue to L1 ; ECM ; extracellular matrix ; FNIII-like ; fibronectin type III-like repeat ; Ig-like ; immunoglobulin-like ; IgSF ; immunoglobulin superfamily ; NrCAM ; NgCAM-related cell adhesion molecules ; NF ; neurofascin
- 刊名：The International Journal of Biochemistry and Cell Biology
- 出版年：2012
- 期刊代码：127_13572725
- 类别：med
- 出版时间：May, 2012
- 卷：44
- 期：5
- 页码：694-697
- 文件大小：335 K
摘要
Neurofascin (NF) is a cell surface protein belonging to the immunoglobulin superfamily (IgSF). Different polypeptides of 186, 180, 166 and 155 kDa are generated by alternative splicing. Expression of these isoforms is temporally and spatially regulated and can be roughly grouped into embryonic, adult and glial expression. NF interacts with many different interaction partners both extra- and intracellularly. Interactions of NF166 and NF180 selectively regulate mechanisms of plasticity like neurite outgrowth and the formation postsynaptic components. By contrast, NF155 and NF186 confer stabilization of neural structures by interaction with voltage-gated sodium channels and ankyrinG at axon initial segments (AIS) or nodes of Ranvier as well as neuron-glia interactions at the paranodes. Alternatively spliced isoforms of neurofascin may therefore balance dynamic and stabilizing mechanisms of the CNS.