Optimal descriptors, calculated with simplified molecular input line entry system have been used for modeling solubility of fullerene C
60 in organic solvents. Statistical characteristics of the model are
n = 92,
R2 = 0.8612,
Q2 = 0.8537,
s = 0.401,
F = 558 (training set)
n = 30,
R2 = 0.8908,
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,
s = 0.435,
F = 228 (test set). The applied approach entirely based on topological data provides a reliable model for solubility of C
60.