Emerging roles for TNIP1 in regulating post-receptor signaling

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• 作者：Vincent P. Ramirez^a  ; [Author Vitae] ; Igor Gurevich^b  ; [Author Vitae] ; Brian J. Aneskievich^b ; ^c ; ^{brian.aneskievich@uconn.edu}  ; [Author Vitae]
• 关键词：TNIP1 ; ABIN-1 ; TNF伪 receptor ; Nuclear receptor ; Inflammation
• 刊名：Cytokine and Growth Factor Reviews
• 出版年：2012
• 期刊代码：62_13596101
• 类别：bio
• 出版时间：June, 2012
• 卷：23
• 期：3
• 页码：109-118
• 文件大小：746 K

摘要

A vast number of cellular processes and signaling pathways are regulated by various receptors, ranging from transmembrane to nuclear receptors. These receptor-mediated processes are modulated by a diverse set of regulatory proteins. TNF伪-induced protein 3-interacting protein 1 is such a protein that inhibits both transduction by transmembrane receptors, such as TNF伪-receptor, EGF-R, and TLR, and nuclear receptors鈥?PPAR and RAR activity. These receptors play key roles in regulating inflammation and inflammatory diseases. A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined. In this review, we aim to integrate the current knowledge of TNIP1s functions with the diseases in which it has been associated to potentially elucidate the role this regulator has in promoting or alleviating these inflammatory diseases.