T_H17 deficiency in human disease

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• 作者：Douglas R. McDonald ; MD ; PhD ; ^{douglas.mcdonald@childrens.harvard.edu}
• 关键词：TH cells ; Candida species ; fungi ; TH17 cell ; pathogen-recognition receptors ; cytokines ; transcription factors ; differentiation ; chronic mucocutaneous candidiasis
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2012
• 期刊代码：158_00916749
• 类别：med
• 出版时间：June, 2012
• 卷：129
• 期：6
• 页码：1429-1435
• 文件大小：344 K

摘要

The differentiation of naive T cells into distinct subsets of effector T cells is critical for effective immunity against a wide variety of infectious agents in the environment. Activation of innate immune responses by Candida species through pattern-recognition receptors directs the subsequent development of naive T cells into T_H17 cells, which are essential for effective mucosal immunity against fungi. Thorough analyses of cohorts of patients with unusual susceptibility to chronic mucocutaneous candidiasis resulting from T_H17 deficiency have confirmed the role of T_H17 cells and T_H17 cytokines in human host defense against Candida species and have provided valuable insights into the complex process of T_H17 cell development.