A QSAR review on melanoma toxicity

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• 作者：Rajeshwar P. Verma ; Suresh B. Mekapati ; Alka Kurup and Corwin Hansch
• 关键词：QSAR ; Melanoma cells ; Hydrophobicity ; Molar refractivity ; Sterimol parameters
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2005
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：2005
• 卷：13
• 期：19
• 页码：5508-5526
• 文件大小：619 K

摘要

Melanoma is one of the most aggressive forms of skin cancer and is currently attracting our attention particularly in the area of quantitative structure–activity relationships (QSAR). In the present review, an attempt has been made to collect the data for different sets of compounds and to discuss their toxicities toward melanoma cells by the formulation of a total number of 36 QSAR.