Studies on synthesis and evaluation of quantitative structure–activity relationship of 5-[(3′-chloro-4′,4′-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dich
- 作者：Sharma ; Pratibha ; Kumar ; Ashok ; Sharma ; Shikha ; Rane ; Nilesh
- 关键词：Indolizine ; Azetidine ; Synthesis ; Antibacterial ; Antifungal ; QSAR ; Molar refractivity
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2005
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：February 15, 2005
- 卷：15
- 期：4
- 页码：937-943
- 文件大小：148 K
摘要
A new series of 5-[(3芒芒芒-chloro-4芒芒芒,4芒芒芒-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides has been synthesized and subjected to acute antibacterial and antifungal screening studies. All the derivatives belonging to this series delineated remarkable activity as compared to standard drugs (ampicillin and clotrimazole). Compounds are quantitatively analyzed in relation to their different physicochemical parameters. Significant correlations were obtained between biological activity and polarizability parameter (MR).