Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence
- 作者：Warren K. Bickel ; wkbickel@vt.edu ; David P. Jarmolowicz ; E. Terry Mueller ; Mikhail N. Koffarnus ; Kirstin M. Gatchalian
- 关键词：Delay discounting ; Trans-disease process ; Neuroscience ; Addiction ; Gambling ; Obesity ; Health behaviors
- 刊名：Pharmacology and Therapeutics
- 出版年：2012
- 期刊代码：41_01637258
- 类别：pha
- 出版时间：June, 2012
- 卷：134
- 期：3
- 页码：287-297
- 文件大小：352 K
摘要
Delay discounting describes the devaluation of a reinforcer as a function of the delay until its receipt. Although all people discount delayed reinforcers, one consistent finding is that substance-dependent individuals tend to discount delayed reinforcers more rapidly than do healthy controls. Moreover, these higher-than-normal discounting rates have been observed in individuals with other behavioral maladies such as pathological gambling, poor health behavior, and overeating. This suggests that high rates of delay discounting may be a trans-disease process (i.e., a process that occurs across a range of disorders, making findings from one disorder relevant to other disorders). In this paper, we argue that delay discounting is a trans-disease process, undergirded by an imbalance between two competing neurobehavioral decision systems. Implications for our understanding of, and treatment for, this trans-disease process are discussed.