Mycoplasma hominis in Cuban Trichomonas vaginalis isolates: Association with parasite genetic polymorphism

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• 作者：Jorge Fraga^a ; ^{fraga@ipk.sld.cu} ; Nadia Rodrí ; guez^b ; Carmen Ferná ; ndez^b ; Brian Mondeja^b ; Idalia Sariego^a ; Aymé ; Ferná ; ndez-Calienes^a ; Lazara Rojas^a
• 关键词：Trichomonas vaginalis ; RAPD ; Polymorphism ; Resistance ; Mycoplasma hominis
• 刊名：Experimental Parasitology
• 出版年：2012
• 期刊代码：99_00144894
• 类别：imm
• 出版时间：July, 2012
• 卷：131
• 期：3
• 页码：393-398
• 文件大小：340 K

摘要

Trichomonas vaginalis can be naturally infected with intracellular Mycoplasma hominis. This bacterial infection may have implications for trichomonal virulence and disease pathogenesis. The objective of the study was to report the presence of M. hominis in Cuban T. vaginalis isolates and to describe the association between the phenotype M. hominis infected with RAPD genetic polymorphism of T. vaginalis. The Random Amplified Polymorphic DNA (RAPD) technique was used to determine genetic differences among 40 isolates of T. vaginalis using a panel of 30 random primers and these genetic data were correlated with the infection of isolates with M. hominis. The trees drawn based on RAPD data showed no relations with metronidazole susceptibility and significantly association with the presence of M. hominis (P = 0.043), which demonstrates the existence of concordance between the genetic relatedness and the presence of M. hominis in T. vaginalis isolates. This result could point to a predisposition of T. vaginalis for the bacterial enters and/or survival.