Ionic liquid mediated 1,3-dipolar cycloaddition of azomethine ylides: a facile and green synthesis of novel dispiro heterocycles

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• 作者：Renuka Jain ; ^{profrjain@rediffmail.com} ; Kanti Sharma ; Deepak Kumar
• 关键词：1 ; 3-Dipolar cycloaddition ; Azomethine ylide ; Spiro-oxindole ; Ionic liquid ; Environmentally benign
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：11 April, 2012
• 卷：53
• 期：15
• 页码：1993-1997
• 文件大小：291 K

摘要

A greener, facile and efficient one-pot, three-component procedure for the synthesis of novel dispiropyrrolidine-bisoxindole derivatives by cycloaddition trapping of azomethine ylides generated in situ, via decarboxylative condensation of isatin with sarcosine (伪-amino acid), has been reported in [bmim]PF₆, an ionic liquid as a recyclable solvent in excellent yield without using any catalyst. This protocol provides mild reaction conditions, high yields of product in short reaction time, high regio- and stereoselectivity, operational simplicity and environmentally benign procedure.