- 作者：Hironori Koga&lowast ; ; Satoshi Hagiwara ; M.D. ; Ph.D.&lowast ; ; saku@oita-u.ac.jp ; Hideto Mei&lowast ; ; Nozomi Hiraoka ; M.D. ; Ph.D.&lowast ; ; Jyunya Kusaka ; M.D. ; Ph.D.&lowast ; ; Koji Goto ; M.D. ; Ph.D.&lowast ; ; Kenji Kashima ; M.D. ; Ph.D.&dagger ; ; Takayuki Noguchi ; M.D. ; Ph.D.&lowast ;
- 关键词：cytokine ; myeloperoxidase ; acute kidney injury ; ischemia-reperfusion ; vitamin E
- 刊名：Journal of Surgical Research
- 出版年：2012
- 期刊代码：299_00224804
- 类别：med
- 出版时间：July, 2012
- 卷：176
- 期：1
- 页码：220-225
- 文件大小：1051 K
Background
Acute kidney injury (AKI), which occurs during renal transplantation and cardiovascular surgery, is a major clinical problem associated with high mortality, and has limited treatment options. Anti-inflammation therapy has been suggested to improve the course and outcome of AKI. In this study, we hypothesized that ESeroS-GS, a vitamin E derivative, inhibits cytokine production and prevents renal ischemia-reperfusion (I/R) injury in rats.Methods
Rats received an intravenous infusion of ESeroS-GS or saline, and underwent experimentally-induced renal I/R injury or sham treatment. Rats were sacrificed after 60 min of ischemia and 24 h of reperfusion. To evaluate the renal protective effects of ESero-GS, renal function was examined, kidneys were histologically assessed, levels of myeloperoxidase (MPO) and serum cytokines were measured, and caspase 3/7 activity was determined.
Results
ESeroS-GS attenuated I/R-induced histologic alterations, reduced levels of MPO and serum BUN, Cre, TNF-伪, and IL-6, and decreased caspase 3/7 activity in kidneys of rats subjected to renal I/R injury.
Conclusions
ESeroS-GS attenuated renal injury after I/R by reducing serum cytokine levels. Our findings suggest that ESeroS-GS may have therapeutic potential against various human I/R conditions.