pH-responsive magnetic mesoporous silica nanospheres for magnetic resonance imaging and drug delivery

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• 作者：Huixia Wu^a ; ^{wuhuixia@shnu.edu.cn} ; Lihui Tang^a ; Lu An^a ; Xue Wang^a ; Haoqiang Zhang^a ; Jianlin Shi^b ; Shiping Yang^a
• 关键词：Mesoporous silica nanospheres ; Magnetite ; Poly(acrylic acid) ; Magnetic resonance imaging ; Drug delivery
• 刊名：Reactive and Functional Polymers
• 出版年：2012
• 期刊代码：92_13815148
• 类别：ch
• 出版时间：May, 2012
• 卷：72
• 期：5
• 页码：329-336
• 文件大小：1374 K

摘要

Multi-functional magnetic mesoporous silica nanospheres (MMSNs), which were coated with poly(acrylic acid) (PAA), have been synthesized using the atom transfer radical polymerization of tert-butyl acrylate on the surface of MMSNs followed by the hydrolysis of the grafted poly(tert-butyl acrylate) chains. The resulting MMSN-PAA nanocomposites exhibit negligible cytotoxicity toward HeLa and L02 cells. Magnetic resonance imaging (MRI) studies reveal that the nanocomposites can be effectively taken-up by the cancer cells. The anticancer drug doxorubicin hydrochloride (DOX) can be loaded into the nanocomposites and subsequently released in a sustained and pH-responsive way because of the presence of pH-sensitive polymer shells. The DOX-loaded nanocomposites exhibit notable cytotoxicity to HeLa cancer cells. These results demonstrate that the pH-responsive MMSN-PAA nanocomposites can be applied to biological systems for MRI and drug delivery.