We retrospectively reviewed the charts of 112 consecutive patients hospitalized for DAH in a tertiary referral center over a 30-year period.
Twenty-four causes of DAH were classified into four etiologic groups: immune (n聽=聽39), congestive heart failure (CHF; n聽=聽33), miscellaneous (n聽=聽26), and idiopathic DAH (n聽=聽14). Based on this classification, clinical and laboratory features of DAH differed on hospital admission. Patients with immune DAH had more frequent pulmonary-renal syndrome (p聽<聽0.001), extra-pulmonary symptoms (p聽<聽0.01), and lower blood hemoglobin level than others (p聽<聽0.001). Patients with CHF-related DAH were older and received more anticoagulant treatments than others (p聽<聽0.05). Those with miscellaneous causes of DAH exhibited a shorter prodromal phase (p聽<聽0.001) and had more frequent hemoptysis >200聽mL (p聽<聽0.05). Patients with idiopathic DAH had more bronchoalveolar lavage siderophages (p聽<聽0.01). In-hospital mortality was 24.1%, ranging from 7.1%in patients with idiopathic DAH to 36.4%in those with CHF.
Arbitrary classification of DAH in four etiologic groups gives the opportunity to underline distinct presentations and outcomes of various causes of DAH.