Cardioventilatory coupling and inter-breath variability in children referred for polysomnography

详细信息	查看全文 | 推荐本文 |

• 作者：D.E. Elder^a ; ^{dawn.elder@otago.ac.nz} ; P.D. Larsen^b ; A.J. Campbell^c ; D.C. Galletly^b
• 关键词：Respiratory variability ; Cardioventilatory coupling ; Children
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2012
• 期刊代码：185_15699048
• 类别：bio
• 出版时间：15 April, 2012
• 卷：181
• 期：1
• 页码：1-7
• 文件大小：524 K

摘要

Measures of respiratory variability including cardioventilatory coupling (CVC), were examined in 8 Down syndrome (DS), 4 Prader Willi syndrome (PWS) and 42 non-syndromic children (median age 7 years) referred for diagnostic polysomnography. Inspiratory onsets (I) and corresponding ECG R waves were determined, I-I, R-R and R-I intervals derived, and ventilatory frequency (f), standard deviation of f (SDf), coefficient of variation of f (CVf), median I-I and kurtosis and skewness I-I calculated. Proportional Shannon Entropy of the RI_鈭? interval (SH伪) was measured to quantitate CVC. SH伪 varied with age (p = 0.02), oxygen saturation (p < 0.05) and PWS diagnosis (p = 0.001) in Stage 4 but not REM sleep. SDf and CVf varied with sleep state (p < 0.00001) as did kurtosis I-I (p < 0.0001) and skewness I-I (p = 0.004). Ventilatory frequency decreased with age in REM sleep (p = 0.03) and increased in obese children in REM (p = 0.02) and Stage 4 sleep (p = 0.004). Sleep state influences respiratory variability in children and CVC may confer a physiological advantage in children with PWS.