Using respondent-driven sampling for behavioural surveillance: Response to Scott
- 作者：Amy Lansky ; Timothy D. Mastro
- 关键词：CNS ; Food intake ; Obesity ; Anorexia ; Neuropeptides
- 刊名：The International Journal of Drug Policy
- 出版年：2008
- 期刊代码：129_09553959
- 类别：med
- 出版时间：June 2008
- 卷：19
- 期：3
- 页码：241-243
- 文件大小：105 K
摘要
The Allen Brain Atlas, the most comprehensive in situ hybridization database, covers over 21,000 genes expressed in the mouse brain. Here we discuss the feasibility to utilize the ABA in research pertaining to the central regulation of feeding and we define advantages and vulnerabilities associated with the use of the atlas as a guidance tool. We searched for 57 feeding-related genes in the ABA, and of those 42 display distribution consistent with that described in previous reports. Detailed analyses of these 42 genes in the nucleus accumbens, ventral tegmental area, nucleus of the solitary tract, lateral hypothalamus, arcuate, paraventricular, ventromedial and dorsomedial nuclei suggests that molecules involved in feeding stimulation and termination are coexpressed in multiple consumption-related sites. Gene systems linked to energy needs, reward or satiation display a remarkably high level of overlap. This conclusion calls into question the classical concept of brain sites viewed as independent hunger or reward “centers” and favors the theory of a widespread feeding network comprising multiple neuroregulators affecting numerous aspects of consumption.