Magnetically targeted drug delivery during cardiopulmonary resuscitation and the post-resuscitation period

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• 作者：Theodoros Xanthos^a ; Michael Chatzigeorgiou^b ; Elizabeth O. Johnson^a ; Athanasios Chalkias^a ; ^{thanoschalkias@yahoo.gr}
• 关键词：Cardiopulmonary resuscitation ; Post-cardiac arrest period ; Treatment ; Magnetically targeted drug delivery
• 刊名：Resuscitation
• 出版年：2012
• 期刊代码：236_03009572
• 类别：med
• 出版时间：July, 2012
• 卷：83
• 期：7
• 页码：803-805
• 文件大小：213 K

摘要

Treatment with pharmacological agents is frequently required during cardiopulmonary resuscitation efforts and almost always during the post-resuscitation period. However, the lack of scientific evidence, the potent side effects and the association of resuscitation drugs with poor outcome act as a disincentive for their use. The use of magnetic nanoparticles in medicine has great potential. Magnetically targeted drug delivery may be an ideal method of pharmaceutical treatment during the resuscitation efforts and post-resuscitation period. In addition, there is evidence that magnetic nanotechnology may be used in the detection of post-cardiac arrest brain injury. In the light of poor survival of cardiac arrest victims, research in cardiopulmonary resuscitation should focus on this promising technology as soon as possible.