Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy

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• 作者：Magali Gary-Bobo^a ; Youssef Mir^b ; Cé ; dric Rouxel^b ; David Brevet^c ; Ouahiba Hocine^c ; Marie Maynadier^a ; Audrey Gallud^a ; Afitz Da Silva^a ; Olivier Mongin^b ; Mireille Blanchard-Desce^b ; ^{mireille.blanchard-desce@u-bordeaux1.fr} ; Sé ; bastien Richeter^c ; Bernard Loock^d ; ^e ; Philippe Maillard^d ; ^e ; Alain Morè ; re^a ; Marcel Garcia^a ; ^{Marcel.garcia@inserm.fr} ; Laurence Raehm^c ; Jean-Olivier Durand^c ; ^{durand@univ-montp2.fr}
• 关键词：Mesoporous silica nanoparticles ; Two-photon ; Photodynamic therapy ; Drug delivery ; Mannose ; Galactose ; Targeting ; Retinoblastoma
• 刊名：International Journal of Pharmaceutics
• 出版年：2012
• 期刊代码：24_03785173
• 类别：pha
• 出版时间：1 August, 2012
• 卷：432
• 期：1-2
• 页码：99-104
• 文件大小：707 K

摘要

In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.