Multiple-dose vaginal misoprostol and single-dose misoprostol plus oxytocin for termination of second-trimester pregnancy

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• 作者：Maryam Zangeneh ; ^{mzangene.59710@yahoo.com} ; Shohreh Malek-Khosravi ; Firoozeh Veisi ; Negin Rezavand ; Mansour Rezaee ; Mozhgan Rajatee
• 关键词：Abortion ; Misoprostol ; Oxytocin ; Second-trimester pregnancy
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2012
• 期刊代码：130_00207292
• 类别：med
• 出版时间：April, 2012
• 卷：117
• 期：1
• 页码：78-80
• 文件大小：112 K

摘要

Objective

To compare 2 different methods鈥攎ultiple doses of misoprostol and a combination of misoprostol and oxytocin鈥攆or termination of pregnancy in the second trimester.

Methods

Between 2006 and 2008, 120 women undergoing termination of second-trimester pregnancy in 2 hospitals in Kermanshah, Iran, were enrolled in a randomized trial comparing 2 treatments. In each treatment group, an initial vaginal dose of 600 渭g of misoprostol was placed in the posterior fornix. After 6 hours, an intravenous infusion of concentrated oxytocin was given to women in group A, and 400 渭g of vaginal misoprostol was given every 6 hours to women group B, up to a maximum of 4 doses. The outcomes were compared via 蠂² and independent t tests.

Results

Within 30 hours, 96.7%of women in group A and 96.7%of women in group B delivered successfully. The average duration between induction and delivery time was 12.3 卤 6.0 hours in group A and 12.1 卤 6.0 hours in group B (P > 0.05).

Conclusion

The use of misoprostol with oxytocin, and multiple doses of misoprostol gave similar results for termination of pregnancy in the second trimester.