l-Proline-catalyzed diastereoselective synthesis of cis-isoquinolonic acids and evaluation of their neuroprotective effects

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• 作者：Ali Reza Karimi^a ; ^{a-karimi@araku.ac.ir} ; Hamid Reza Momeni^b ; Rahim Pashazadeh^a
• 关键词：l-Proline ; Isoquinolonic acids ; Multi-component reaction ; Diastereoselective synthesis ; Neuroprotective effects
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：4 July, 2012
• 卷：53
• 期：27
• 页码：3440-3443
• 文件大小：343 K

摘要

l-Proline efficiently catalyzes the one-pot, three-component reaction of homophthalic anhydride, amines, and aldehydes in CH₃CN at room temperature, to afford the corresponding cis-isoquinolonic acids in high yields and with excellent diastereoselectivities. The synthesized compounds are screened for neuroprotective activities.