Processes for Quality Improvements in Radiation Oncology Clinical Trials
- 作者：T.J. FitzGerald ; Marcia Urie ; Kenneth Ulin ; Fran Laurie ; Jeffrey Yorty ; Richard Hanusik ; S ; y Kessel ; Maryann Bishop Jodoin ; Gani Osagie ; M. Giulia Cicchetti ; Richard Pieters ; Kathleen McCarten ; Nancy
- 关键词：Clinical trials ; Quality assurance
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2008
- 期刊代码：136_03603016
- 类别：med
- 出版时间：1 May 2008
- 卷：71
- 期：1, Supplement 1
- 页码：S76-S79
- 文件大小：102 K
摘要
The concise and divergent total syntheses of (−)-swainsonine, (−)-7-alkyl swainsonines, and (−)-2,8a-diepilentiginosine from a common chiral heterocyclic enaminoester intermediate in five-step sequences are presented. The highly efficient annulation reaction of the chiral heterocyclic enaminoester with various 
,β-unsaturated carboxylates, and a straightforward carboxy inversion constituted the key features of the synthetic pathway. This work provides an example for divergent synthesis of different natural and unnatural polyhydroxylated indolizidines from a readily available platform.
,β-unsaturated carboxylates, and a straightforward carboxy inversion constituted the key features of the synthetic pathway. This work provides an example for divergent synthesis of different natural and unnatural polyhydroxylated indolizidines from a readily available platform.