An efficient 1,2,4-triazine-based route to the louisianin alkaloids

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• 作者：Nicola Catozzi ; Pierre Wasnaire ; Richard J.K. Taylor
• 关键词：Mö ; bius– ; Kantor graph ; Semisymmetric graph ; Arc-transitive graph
• 刊名：Tetrahedron Letters
• 出版年：2008
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：28 April 2008
• 卷：49
• 期：18
• 页码：2865-2868
• 文件大小：125 K

摘要

A new, short and efficient route to louisianins C and D is described in which the pyridine ring is constructed from a disubstituted 1,2,4-triazine by an inverse-electron-demand Diels–Alder/retro-Diels–Alder/aromatisation cascade sequence. This eight-step route produces louisianin C in 16%overall yield from the commercially available 5-chloropent-1-yne.