The relation between uric acid serum levels and cardiovascular disease has been known for a long time. However, it has been in recent times that we have found growing evidence that establishes the possible pathogenic role of uric acid in the different manifestations of cardiovascular disease. The importance of this relation continues to be cause of controversy and the debate is still open on whether we should consider hyperuricemia as an independent vascular risk factor or if it is a mere epiphenomenon of the vascular or metabolic disease.
This review aims to go over the evidence on these aspects again and to analyze the therapeutic implications that the new knowledge may involve.