A virosomal vaccine against candidal vaginitis: Immunogenicity, efficacy and safety profile in animal models
- 作者：Flavia De Bernardis
- 关键词：Candida albicans ; Aspartyl proteinase 2 ; Virosomes ; Vaccine ; Recurrent vulvo-vaginal candidiasis
- 刊名：Vaccine
- 出版年：2012
- 期刊代码：89_0264410x
- 类别：imm
- 出版时间：22 June, 2012
- 卷：30
- 期：30
- 页码：4490-4498
- 文件大小：421 K
摘要
A novel vaccine (PEV7) consisting of a truncated, recombinant aspartyl proteinase-2 of Candida albicans incorporated into influenza virosomes was studied. This vaccine candidate generated a potent serum antibody response in mouse and rat following intramuscular immunization. Anti-Sap2 IgG and IgA were also detected in the vaginal fluid of rats following intravaginal or intramuscular plus intravaginal administration. In a rat model of candidal vaginitis, PEV7 induced significant, long-lasting, likely antibody-mediated, protection following intravaginal route of immunization. PEV7 was also found to be safe in a repeated-dose toxicological study in rats. Overall, these data provide a sound basis to envisage the clinical development of this new candidate vaccine against candidal vaginitis.