A tridimensional view of pituitary development and function

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• 作者：Patrice Mollard¹ ; ² ; ³ ; ^{patrice.mollard@igf.cnrs.fr} ; David J. Hodson¹ ; ² ; ³ ; ⁴ ; Chrystel Lafont¹ ; ² ; ³ ; Karine Rizzoti⁵ ; Jacques Drouin⁶ ; ^{jacques.drouin@ircm.qc.ca}
• 关键词：development ; physiology ; systems biology
• 刊名：Trends in Endocrinology and Metabolism
• 出版年：2012
• 期刊代码：149_10432760
• 类别：bio
• 出版时间：June, 2012
• 卷：23
• 期：6
• 页码：261-269
• 文件大小：1698 K

摘要

Recent advances in tridimensional (3D) tissue imaging have considerably enriched our view of the pituitary gland and its development. Whereas traditional histology of the pituitary anterior lobe portrayed this tissue as a patchwork of cells, 3D imaging revealed that cells of each lineage form extensive and structured homotypic networks. In the adult gland these networks contribute to the robustness and coordination of the cell response to secretagogs. In addition, the network organization adapts to changes in endocrine environment, as revealed by the sexually dimorphic growth hormone (GH) cell network. Further work is required to establish better the molecular basis for homotypic and heterotypic interactions in the pituitary as well as the implications of these interactions for pituitary function and dysfunction in humans.