Association between tumor necrosis factor (TNF)-α G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction
- 作者：Attila Molvarec ; Á ; gnes Jermendy ; Bá ; lint Nagy ; Margit Ková ; cs ; Tibor Vá ; rkonyi ; Petronella Hupuczi ; Zoltá ; n Prohá ; szka ; Já ; nos Rigó ; Jr.
- 关键词：Tumor necrosis factor ; Polymorphism ; Preeclampsia ; Fetal growth restriction ; HELLP syndrome
- 刊名：Clinica Chimica Acta
- 出版年：2008
- 期刊代码：54_00098981
- 类别：med
- 出版时间：June 2008
- 卷：392
- 期：1-2
- 页码：52-57
- 文件大小：190 K
摘要
Preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome are multifactorial disorders with genetic and environmental components. Given that the tumor necrosis factor (TNF)-
G-308A single nucleotide polymorphism (SNP) affects TNF- gene transcription and that preeclampsia and HELLP syndrome are characterized by a shift towards a Th1-type maternal immune response with increased TNF- production, the aim of the current study was to investigate whether this SNP is associated with preeclampsia and HELLP syndrome in a Caucasian population from Hungary. Additionally, we aimed to examine whether TNF- G-308A polymorphism can influence the risk for fetal growth restriction in preeclamptic patients, which issue none of the earlier studies dealt with.
G-308A single nucleotide polymorphism (SNP) affects TNF- gene transcription and that preeclampsia and HELLP syndrome are characterized by a shift towards a Th1-type maternal immune response with increased TNF- production, the aim of the current study was to investigate whether this SNP is associated with preeclampsia and HELLP syndrome in a Caucasian population from Hungary. Additionally, we aimed to examine whether TNF- G-308A polymorphism can influence the risk for fetal growth restriction in preeclamptic patients, which issue none of the earlier studies dealt with.