Platelet-Rich Plasma Injections and Surgery: Short-Term Outcomes and Long-Term Prognosis
- 作者：Rocco Papalia ; MD鈦?/sup> ; Sebastiano Vasta ; MD鈦?/sup> ; Biagio Zampogna ; MD鈦?/sup> ; Andrea Tecame鈦?/sup> ; Nicola Maffulli ; MD ; MS ; PhD ; FRCS(Orth)&dagger ; ; n.maffulli@qmul.ac.uk ; Vincenzo Denaro ; MD鈦?/sup> ; &Dagger ;
- 关键词：PRP ; surgery ; tendinopathy ; ligaments ; clinical outcomes
- 刊名：Operative Techniques in Orthopaedics
- 出版年：2012
- 期刊代码：238_10486666
- 类别：med
- 出版时间：June, 2012
- 卷：22
- 期：2
- 页码：71-77
- 文件大小：221 K
摘要
Platelet-rich plasma (PRP) is a blood derivate that contains a high value of platelet concentration, a variable number of red blood cells and white blood cell according to the method of preparation. Platelet-derived growth factors are powerful and promising molecules that could be useful in the management of sport-associated injuries, such as tendinopathies, muscular lesions, and cartilage damages, and to improve graft tissue healing. Uncontrolled studies on tendinopathy reported nearly universally good-to-excellent results after treatment with PRP, but this was not the case when controlled studies were undertaken. The studies that augmented surgically repaired tendons or ligaments do not allow reaching a definitive conclusion鈥攖oo many variables could influence the outcomes. To understand which disorders are more susceptible to the effects of PRP, more basic science studies and better designed clinical studies comparing a standardized PRP formulation are necessary.