Laparoscopic surgical exploration is an effective strategy for locating occult primary neuroendocrine tumors

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• 作者：Kristen P. Massimino ; M.D.^a ; Esther Han ; M.D.^a ; SuEllen J. Pommier ; Ph.D.^b ; Rodney F. Pommier ; M.D.^b ; ^{pommierr@ohsu.edu}
• 关键词：Neuroendocrine tumor ; Carcinoid ; Occult primary ; Laparoscopy
• 刊名：The American Journal of Surgery
• 出版年：2012
• 期刊代码：9_00029610
• 类别：med
• 出版时间：May, 2012
• 卷：203
• 期：5
• 页码：628-631
• 文件大小：143 K

摘要

Background

Many patients with neuroendocrine tumors (NETs) have metastases at diagnosis. Despite extensive metastases the primary tumors remain small and difficult to locate.

Methods

Records of patients diagnosed with metastatic abdominal NETs from 2006 to 2010 were reviewed retrospectively. Results of preoperative imaging, procedures, and surgical explorations were compared for their efficacy at finding primary tumors.

Results

Sixty-three patients were identified. Seventeen percent (11 of 63) of tumors were located by preoperative testing. The sensitivities of preoperative colonoscopy (23%[n = 26]), computed tomography scan (6.7%[n = 60]), and somatostatin receptor scintigraphy (2.0%[n = 52]) were low. No tumors were found by magnetic resonance imaging (n = 9), upper endoscopy (n = 24), capsule endoscopy (n = 2), or bronchoscopy (n = 4). Surgical exploration was the most sensitive (79%[n = 63]) method of tumor detection. Seventy-two percent of surgical localizations were laparoscopic.

Conclusions

Surgical exploration was superior to all other modalities for locating primary NETs. Laparoscopy had a high probability of finding occult primary neuroendocrine tumors.