- 作者：P.C. Notta ; D. Ramal ; S. Maisterra ; A. Rodrí ; guez Gasen ; S. Maymó ; A. Sabaté ; A. Girbau ; J. Guardiola ; J. Martí ; n-Comí ; n<sup> ; sup><sup>jmartincomin@bellvitgehospital.catsup>
- 关键词：75Se-SEHCAT ; Diarrea cró ; nica ; Absorció ; n de á ; cidos biliares
- 刊名：Revista Espa帽ola de Medicina Nuclear
- 出版年：2011
- 期刊代码：pca315_02126982
- 类别：med
- 出版时间：September-October 2011
- 卷：30
- 期：5
- 页码：297-300
- 文件大小：183 K
ss="h4">Aim
To evaluate the usefulness of the <sup>75sup>SeHCAT abdominal retention (AR) measurement in the early diagnosis of diarrhea syndrome (DS).
ss="h4">Methods
Thirty-seven patients with diarrhea syndrome within the first month of evolution were prospectively evaluated. The <sup>75sup>Se-SeHCAT abdominal retention was measured 4 and 7 days post-administration of 0.01 mCi of <sup>75sup>SeHCAT. The test was performed prior to treatment and at 3 months when the baseline study was positive. The test was considered positive if the RA was <25%at 4<sup>thsup> and <10%on the 7th day. The patients were visited at 3 months. Depending on the response, 3 groups were established: a) complete response: normalization of stool frequency, b) partial response, decrease of frequency or c) no response.
ss="h4">Results
Group A: The AR of <sup>75sup>Se-SEHCAT was normal in 21 patients. Six were diagnosed of colonic diverticulosis, 8 of irritable bowel syndrome, 1 of lymphocytic colitis, 1 of post-gastroenteritis syndrome, 1 of celiac disease and 1 of stenosis of the cardia. Four are still under study. Group B: The AR of <sup>75sup>Se-SEHCAT decreased in 16 patients. All showed abnormal AR at day 7 and all but 1 at day 4. Following administration of cholestyramine resin, 8 (50%) presented partial response and 8 (50%) complete response. At 3 months, AR had increased at day 4 and 9 at day 7.
ss="h4">Conclusion
The measurement of <sup>75sup>SEHCAT abdominal retention allows the early diagnosis of bile acid malabsorption in 43%of the patients with DS. Measurement at 7 days seems more accurate than that at 4 days.