Detection of subclinical atherosclerosis in familial hypercholesterolemia using non-invasive imaging modalities

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• 作者：Paloma Caballero^a ; ¹ ; Rodrigo Alonso^b ; ¹ ; ^{ralonso@fjd.es} ; ^{rodrigoalonsok@telefonica.net} ; Paloma Rosado^a ; Nelva Mata^c ; Leticia Ferná ; ndez-Friera^d ; Luis Jesú ; s Jim&eacute ; nez-Borreguero^e ; Lina Badimon^f ; Pedro Mata^b
• 关键词：Familial Hypercholesterolemia ; MRI ; Ultrasound ; Atherosclerosis ; Aorta
• 刊名：Atherosclerosis
• 出版年：2012
• 期刊代码：28_00219150
• 类别：med
• 出版时间：June, 2012
• 卷：222
• 期：2
• 页码：468-472
• 文件大小：313 K

摘要

Objectives

To investigate the extent of subclinical atherosclerosis in asymptomatic familial hypercholesterolemia (FH) patients using non-invasive images techniques.

Patients, methods and results

The atherosclerotic burden of 36 molecularly defined FH patients (18 males, 45.7 卤 10.9 years) without evidence of cardiovascular disease receiving lipid-lowering treatment and 19 (47.8 卤 11.3 years) controls was investigated. Descending thoracic aorta magnetic resonance imaging (MRI) was performed in a 1.5 T equipment with T1 and T2 sequences to characterize atherosclerotic plaques and to measure aortic wall volumen. Carotid intima-media thickness (cIMT) and presence of plaques were measured using B-mode carotid ultrasound.

Mean aortic wall volumen, cIMT and atherosclerotic plaques in aorta were significantly higher in FH cases (P < 0.001). A significant correlation between aortic wall volume and cIMT was observed (P < 0.01). Aortic MRI detected plaques in 94%and carotid ultrasound in 14%of cases. Lipid-rich plaques were observed only in FH cases (33%) and were associated with family history of premature coronary artery disease (P < 0.05).

Conclusions

Asymptomatic middle-aged FH patients have significantly higher atherosclerotic burden than controls. cIMT has shown a significant correlation with aortic wall volume and MRI allowed the detection of lipid-rich plaques in FH subjects that were associated with family history of premature coronary artery disease.