Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia
- 作者：Helton José ; Reis ; Rodrigo Nicolato ; Izabela Guimarã ; es Barbosa ; Paulo Henrique Teixeira do Prado ; Marco Auré ; lio Romano-Silva ; Antonio Lucio Teixeira
- 关键词：BDNF ; Schizophrenia ; Negative symptoms
- 刊名：Neuroscience Letters
- 出版年：2008
- 期刊代码：52_03043940
- 类别：neu
- 出版时间：11 July 2008
- 卷：439
- 期：2
- 页码：157-159
- 文件大小：179 K
摘要
There is a growing body of evidence implicating the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathogenesis of schizophrenia. As circulating BDNF levels may reflect the BDNF levels in the brain, we assessed serum BDNF in 40 institutionalized schizophrenic patients and 20 healthy controls. Serum BNDF levels were significantly increased in schizophrenic patients when compared to control subjects (p < 0.001). Interestingly, serum BDNF correlated positively with the clinical scores at the negative subscale of the positive and negative syndrome scale (PANSS) (r = 0.41; p < 0.01). Our results confirm the emergent literature on the involvement of BDNF in schizophrenia.