• 作者：Rafael Gó ; mez Rodrí ; guez^a ; Marta Romero Gutié ; rrez^a ; ^{m.romero.gutierrez@gmail.com} ; Concepció ; n Gonzá ; lez de Frutos^a ; Tomá ; s de Artaza Varasa^a ; Gema de la Cruz Perez^a ; Juan José ; Ciampi Dopazo^b ; Carlos Lanciego Pé ; rez^b ; Ana Zaida Gó ; mez Moreno^b
• 关键词：Carcinoma hepatocelular ; Cribado ; Estadificació ; n BCLC ; Tratamiento
• 刊名：Gastroenterolog铆a y Hepatolog铆a
• 出版年：2011
• 期刊代码：pca167_02105705
• 类别：med
• 出版时间：October 2011
• 卷：34
• 期：8
• 页码：524-531
• 文件大小：187 K

Hepatocellular carcinoma (HCC) is the most frequent cause of mortality in patients with liver cirrhosis. There are no prospective series from a single tertiary hospital in Spain.

Material and Methods

We performed a prospective study of patients with HCC in our center. Clinical and epidemiological characteristics, diagnostic method, staging according to the Barcelona Clinic Liver Cancer (BCLC) system and treatment were analyzed.

Results

A total of 136 patients were included (80.9%men). The mean age was 66.62卤11.68 years and 91.2%were cirrhotic. Hepatitis C virus (HCV) was the leading cause of liver disease (38.97%). The suspected diagnosis was established by a surveillance program in 63.2%. Noninvasive American Association criteria for the Study of Liver Diseases (AASLD) were the main diagnostic method (73.5%). According to the BCLC, 58.1%were in the early stage (0-A), 21.3%in stage B, 12.5%in stage C and 8.1%in stage D. Early stage patients had followed a surveillance program more frequently than those with non-early stages (79.75%versus 44.35%, p <0.001). Potentially curative initial treatment was used in 45.58%, the most common treatment being percutaneous ethanol injection (23.13%).

Conclusions

Most patients with HCC in our hospital have cirrhosis, the most frequent cause being HCV. HCC surveillance in at-risk patients could increase diagnosis of HCC at an early stage. We achieved an early diagnosis in more than half of cases. The most common initial treatment was percutaneous therapy.