Exposure was estimated in 54 workers from a paint company in Mexico City through BTX accumulated potential dose (BTX-APD). Two exposure groups were formed: high and low BTX-APD established with a cutoff point at 鈮?.0 of BTX-APD, as a function of the geometric mean of the estimator鈥檚 value distribution and the higher agreement between BTX-APD 鈮?.0 and the areas referred as using (or not) organic solvents in the work process. IL-10, TNF and IL-12 concentrations were measured with ELISA. Through multiple linear regression models, the production of each of the proposed cytokines and of the whole set was assessed.
Workers with high BTX-APD showed a significant reduction in TNF production (尾聽= 鈭?,196.0 pg/mL; p聽= 0.01); a reduction for IL-10 (尾聽= 鈭?20.3; p聽= 0.13) and IL-12 (尾聽= 鈭?43.3; p聽= 0.09) was also observed, although without statistical significance.
TNF production assessed in workers with a high BTX-APD is lower than in聽those with a low BTX-APD, but not in IL-10 and IL-12 production.