• 作者：Sami Aoufi Rabih^a ; ^{samiaoufi@hotmail.com} ; Rebeca Garc&#237 ; a Agudo^b ; José ; Mar&#237 ; a Ten&#237 ; as Burillo^c ; Francisco Ruiz Carrillo^a ; Pedro Gonzá ; lez Carro^a ; Francisco Pé ; rez Roldá ; n^a ; Marina Ynfante Ferrú ; s^a ; Esther Bernardos Mart&#237 ; n^a ; Ó ; scar Roncero Garc&#237 ; a-Escribano^b ; Mar&#237 ; a Luisa Legaz Huidobro^a ; Natividad Sá ; nchez-Manjavacas^a
• 关键词：Microalbuminuria ; Insuficiencia renal ; virus de la hepatitis C
• 刊名：Gastroenterolog铆a y Hepatolog铆a
• 出版年：2012
• 期刊代码：pca167_02105705
• 类别：med
• 出版时间：May, 2012
• 卷：35
• 期：5
• 页码：309-316
• 文件大小：283 K

Introduction

Chronic hepatitis C virus (HCV) infection is associated with glomerular disease, which is manifested by proteinuria with or without renal dysfunction.

Method

To determine the prevalence of HCV-associated renal injury and associated risk factors, we performed an observational, analytic, cross-sectional study of 120 HCV-positive patients and 145 HCV-negative controls. Data were gathered from medical records and history-taking and at least three blood and urine analyses were performed over a 1-year period. Renal insufficiency was defined as an estimated glomerular filtration rate of less than 60 ml/min/1.73 m2 and/or microalbuminuria of more than 20 mg/l or a microalbumin/creatinine ratio higher than 30 mcg/mg.

Results

The prevalence of microalbuminuria and renal insufficiency was 19.3%and 11.7%in HCV-positive patients versus 10.5%and 0.7%in HCV-negative controls (p 0.04), respectively. A total of 26.1%of HCV-positive patients had signs of renal injury compared with 11.8%of HCV-negative controls (p 0.003). HCV infection was independently and significantly associated with the probability of worsening of renal function. The prevalence of microalbuminuria and renal insufficiency progressively increased with greater age.

Conclusion

HCV-positive patients show a high prevalence of microalbuminuria and renal insufficiency compared with HCV-negative individuals. The risk of HCV-associated renal insufficiency is independent of the presence of other predisposing factors such hypertension and diabetes.