Two new pterosin sesquiterpenes from Pteris multifida Poir

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• 作者：Jicheng Shu^a ; Jianqun Liu^a ; ^{liu5308@sina.com} ; Youquan Zhong^a ; Jinghang Pan^a ; Lifang Liu^b ; ^{liulifang69@126.com} ; Rui Zhang^a
• 关键词：Pteris multifida ; Pterosin sesquiterpene ; Cytotoxicity
• 刊名：Phytochemistry Letters
• 出版年：2012
• 期刊代码：P8_18743900
• 类别：abs
• 出版时间：June, 2012
• 卷：5
• 期：2
• 页码：276-279
• 文件大小：258 K

摘要

Two new pterosin sesquiterpenes named as 2R,3R-13-hydroxy-pterosin L 3-O-尾-d-glucopyranoside (rong class="boldFont">1rong>) and 2R,3S-acetylpterosin C (rong class="boldFont">2rong>), along with a known one, 2S,3S-acetylpterosin C (rong class="boldFont">3rong>), were isolated from the whole plant of Pteris multifida and the 1D and 2D NMR data of rong class="boldFont">3rong> were reported for the first time in this paper. Their structures were elucidated on the basis of mass and spectral evidence. Compounds rong class="boldFont">1rong>-rong class="boldFont">3rong> showed cytotoxicity against HL 60 cells (human leukemia) with the IC₅₀ values of 14.6, 48.3 and 35.7 渭M, respectively.