Cytotoxic cardenolides from the stems of Periploca forrestii

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• 作者：Yong Li ; Yun-Bao Liu ; Shi-Shan Yu ; ^{yushishan@imm.ac.cn} ; Xiao-Guang Chen ; Xian-Fu Wu ; Shuang-Gang Ma ; Jing Qu ; You-Cai Hu ; Jing Liu ; Hai-Ning Lv
• 关键词：Periploca forrestii ; Cardenolides ; Cytotoxic activity
• 刊名：Steroids
• 出版年：2012
• 期刊代码：142_0039128x
• 类别：bio
• 出版时间：April, 2012
• 卷：77
• 期：5
• 页码：375-381
• 文件大小：386 K

摘要

Six new cardenolides, periforosides D-E (rong class="boldFont">1rong>-rong class="boldFont">2rong>), periforgenin C (rong class="boldFont">3rong>) and periforosides F-H (rong class="boldFont">4rong>-rong class="boldFont">6rong>), as well as 10 previously identified cardenolides (rong class="boldFont">7rong>-rong class="boldFont">16rong>) were isolated from the ethanol extract of the stems of Periploca forrestii. The structures of the new compounds were determined using extensive spectroscopic analyses including HRESI-MS, 1D and 2D NMR data. Evaluation of the cytotoxic activity of all the isolated compounds in five different human cancer cell lines indicated that compounds rong class="boldFont">2rong>-rong class="boldFont">6rong>, rong class="boldFont">8rong>, rong class="boldFont">9rong> and rong class="boldFont">12rong>-rong class="boldFont">16rong> have potent activity.