Unambiguous structure of atractyloside and carboxyatractyloside

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• 作者：Jean-Fré ; dé ; ric Sanchez^a ; ^b ; Brice Kauffmann^c ; Axelle Gré ; lard^d ; Corinne Sanchez^a ; ^b ; Vé ; ronique Tré ; zé ; guet^a ; ^b ; Ivan Huc^d ; Guy J.-M. Lauquin^a ; ^b ; ^{guy.lauquin@ibgc.u-bordeaux2.fr} ; ^{guy.lauquin@ibgc.cnrs.fr}
• 关键词：Atractyloside ; Carboxyatractyloside ; Crystallographic structure
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 April, 2012
• 卷：22
• 期：8
• 页码：2973-2975
• 文件大小：450 K

摘要

Atractyloside (ATR) was characterized in 1868 and until now structural studies on diterpenic moiety had been done through the characterization of ATR derivatives; while the glycosidic moiety seemed to be a 尾-d-glucopyranose a recent crystal structure of the mitochondrial ATP/ADP carrier in complex with CATR showed an 伪-d-glucopyranose. We decided to re-examine the ATR and CATR structures by crystallographic study of ATR.