Numerical Abnormalities of Chromosomes 1 and 10 in Endometrial Adenocarcinoma: Fluorescence In Situ Hybridization Analysis of 23 Archival Paraffin-Embedded Samples
- 作者：Muresu ; Rosella ; Cossu ; Antonio ; Scarpa ; Anna Maria ; Volpi ; Emanuela Valeria ; Rocca ; Paolo Cossu ; et. al.
- 刊名：Cancer Genetics and Cytogenetics
- 出版年：1998
- 期刊代码：43_01654608
- 类别：med
- 出版时间：November, 1998
- 卷：107
- 期：1
- 页码：37-42
- 文件大小：334 K
摘要
Retrospective analysis of chromosomal changes in endometrial carcinoma was performed by fluorescence in situ hybridization on free nuclei isolated from formalin-fixed paraffin-embedded tissue. We examined 23 archival samples for numerical aberrations of chromosomes 1 and 10 with the use of specific DNA probes for the pericentromeric and centromeric regions of these two chromosomes. Numerical aberrations of chromosomes 1 and 10 were detected in 39%of the case analyzed, and the frequency of trisomy 10 tended to increase as the histological grade worsened. Our findings confirm the association of cytogenetic anomalies involving chromosomes 1 and 10 with endometrial carcinoma, as reported by other studies, and suggest that changes in centromere 10 copy number may correlate with the degree of tumor differentiation.