• 作者：Fernando Martí ; nez-Valle ; ^{ferranmartinezvalle@gmail.com} ; Mercedes Gironella-Mesa ; Roser Solans-Laqué
• 关键词：Amiloidosis ; Patogé ; nesis ; Nuevos tratamientos
• 刊名：Medicina Cl篓陋nica
• 出版年：2012
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：26 May, 2012
• 卷：138
• 期：15
• 页码：667-672
• 文件大小：288 K

Amyloidosis is a clinical disorder caused by extracellular deposition of proteins that are normally soluble as insoluble fibrils that damage different organs. More than 20 proteins can form amyloid deposits. All types of amyloid fibrils have a secondary structure with a 尾 folded shape that is characteristic and makes them to adopt a green birefringence after stained with Congo red and viewed under cross-polarized light. Amyloidosis can be acquired or hereditary, systemic or localized, and are classified by the fibril precursor protein. Advances in the knowledge of the pathogenesis of amyloidosis allows the development of new diagnostic and therapeutical schemes that are currently under investigation.