Cyclophilin A differentially activates monocytes and endothelial cells: Role of purity, activity, and endotoxin contamination in commercial preparations

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• 作者：Sravan K. Payeli ; Cordelia Schiene-Fischer ; Jan Steffel ; Giovanni G. Camici ; Izabela Rozenberg ; Thomas F. Lü ; scher ; Felix C. Tanner
• 关键词：Cyclophilin A ; Tissue factor ; Lipopolysaccharide ; Monocytes ; Endothelial cells
• 刊名：Atherosclerosis
• 出版年：2008
• 期刊代码：28_00219150
• 类别：med
• 出版时间：April 2008
• 卷：197
• 期：2
• 页码：564-571
• 文件大小：793 K

摘要

Cyclophilin A (CyPA) is a cytoplasmic protein secreted under inflammatory conditions. Extracellular CyPA is detected in atherosclerotic plaques and has been observed to activate endothelial cells as well as monocytes.