Combination of uterine artery Doppler velocimetry and maternal serum placental growth factor estimation in predicting occurrence of pre-eclampsia in early second trimester pregnancy: a prospective cohort study

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• 作者：Sanjib Kumar Ghosh^a ; ^{drsanjib79@gmail.com} ; Shashi Raheja^a ; Anita Tuli^a ; Chitra Raghunandan^b ; Sneh Agarwal^a
• 关键词：Uterine artery Doppler velocimetry (UADV) ; Placental growth factor (PlGF) ; Pre-eclampsia ; Odds ratio ; Logistic regression analysis
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2012
• 期刊代码：92_03012115
• 类别：med
• 出版时间：April, 2012
• 卷：161
• 期：2
• 页码：144-151
• 文件大小：395 K

摘要

Objective

To determine the effectiveness of the combined use of uterine artery Doppler velocimetry (UADV) and estimation of maternal serum placental growth factor (PlGF) levels in early second trimester (20-22 weeks of gestation) in identifying pregnant women at risk of developing pre-eclampsia.

Study design

Prospective cohort study on 1104 pregnant women with singleton pregnancies between May 2009 and December 2010. UADV and maternal serum PlGF estimation were done at 20-22 weeks鈥?gestation. Association between the two variables and the occurrence of pre-eclampsia was analyzed by logistic regression analysis and odds ratio was computed. The results were considered significant when p was <0.05.

Results

Logistic regression analysis showed that both abnormal UADV (odds ratio (OR) 4.1; 95%CI 2.3-7.2; p = 0.000) and serum PlGF < 188 pg/ml (OR 3.6; 95%CI 1.95-6.5; p = 0.000) are independent variables in the occurrence of pre-eclampsia, and the difference between the association of these two variables with pre-eclampsia was statistically insignificant as 95%CI values overlap. Multivariate logistic regression analysis showed that a combination of abnormal UADV and serum PlGF < 188 pg/ml at 20-22 weeks had a very poor association (OR 1.1; 95%CI 0.3-3.8; p = 0.938) with the occurrence of pre-eclampsia, as the 95%CI values encompass 1 and p is >0.05.

Conclusion

UADV and maternal serum PlGF estimation at 20-22 weeks of gestation are strong predictors of the occurrence of pre-eclampsia when used individually but in combination their association with pre-eclampsia is not significant.