The effect of rTMS on auditory hallucinations: Clues from an EEG-rTMS study

详细信息	查看全文 | 推荐本文 |

• 作者：Remko van Lutterveld^a ; ^{R.vanlutterveld@umcutrecht.nl} ; Sanne Koops^b ; Dennis J.L.G. Schutter^c ; Ellen Geertsema^b ; Cornelis J. Stam^d ; René ; S. Kahn^a ; Iris E.C. Sommer^a
• 关键词：Schizophrenia ; EEG ; Hallucinations ; Placebo ; TMS ; Graph analysis
• 刊名：Schizophrenia Research
• 出版年：2012
• 期刊代码：240_09209964
• 类别：med
• 出版时间：May, 2012
• 卷：137
• 期：1-3
• 页码：174-179
• 文件大小：312 K

摘要

Objective

Repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal region has been proposed as a therapeutic option for auditory verbal hallucinations (AVH). However, most large randomized controlled trials failed to demonstrate a superior effect of rTMS treatment as compared to sham. Previous studies applied daily rTMS sessions for one or more weeks to summate its effects. However, the effect of a single rTMS treatment on AVH-severity has never been studied, making it unclear if there is an initial effect that could be increased by repeated treatment.

Methods

In three separate sessions, twenty-four patients with a psychotic disorder received 1-Hz rTMS to the left temporoparietal cortex, its right-sided homologue or a centro-occipital control site. Severity of AVH was assessed before and after each rTMS session and resting-state EEGs were recorded to investigate the neuronal effects of rTMS.

Results

Stimulation of the temporoparietal cortices was not more effective in reducing AVH-severity than control-site stimulation. In addition, EEG-related power and connectivity measures were not affected differently across stimulation sites and changes in neuronal activity did not correlate with changes in AVH-severity.

Conclusions

These results may suggest a placebo effect of a single session of 1-Hz rTMS treatment on AVH-severity.