Quality of life, anorectal and sexual functions after preoperative radiotherapy for rectal cancer: Report of a randomised trial

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• 作者：Lucyna Pietrzak ; Krzysztof Bujko ; Marek P. Nowacki ; Lucyna Kepka ; Janusz Oledzki ; Andrzej Rutkowski ; Jacek Szmeja ; Jozef Kladny ; Dariusz Dymecki ; Andrzej Wieczorek ; Mariusz Pawlak ; Tadeusz Lesniak ; Te
• 关键词：Rectal cancer ; Preoperative radiotherapy
• 刊名：Radiotherapy and Oncology
• 出版年：2007
• 期刊代码：231_01678140
• 类别：med
• 出版时间：September 2007
• 卷：84
• 期：3
• 页码：217-225
• 文件大小：119 K

摘要

Patients (N = 316) with resectable cT3-4 low-lying and mid-rectal cancer were randomised to receive either preoperative 5 × 5 Gy irradiation with subsequent surgery performed within 7 days or chemoradiation (50.4, 1.8 Gy per fraction plus boluses of 5-fluorouracil and leucovorin) followed by surgery after 4–6 weeks. No differences were found in sphincter preservation, survival, local control and late complications. Early complications were less frequent in the short-course group. The aim of this report is to find out whether large doses per fraction of short-course schedule result in more severe anorectal and sexual dysfunction and quality of life (QoL) impairment.

Materials and method

Patients who were free of disease were asked to answer the QLQ-C30 and those without stoma were, additionally, asked to fill in a questionnaire of anorectal (19 items) and sexual function (1 item).

Results

Two hundred and twenty-two patients (86%response rate) completed the QLQ-C30 and 118 (86%response rate) the anorectal–sexual function questionnaire. The median time from surgery to filling in the QLQ-C30 questionnaire was 12 months, and to filling in the anorectal–sexual function questionnaire – 13 months. We did not find significant differences between the randomised groups regarding QoL and the anorectal and sexual functions. Approximately two-thirds of patients had anorectal function impairment. Approximately 20%of patients stated that this considerably influenced their QoL.

Conclusions

QoL and the anorectal and sexual functioning did not differ in patients receiving short-course radiotherapy, as compared to those receiving chemoradiation.