Determination of batch-to-batch variation for fluidized bed granulation

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• 作者：S. Matero ; S. Poutiainen ; J. Leskinen ; M. Hakulinen ; M. Lahtela-Kakkonen ; J. Ketolainen ; R. Lappalainen ; K. Jä ; rvinen ; A. Poso
• 关键词：Antidepressant drugs ; Excitatory postsynaptic currents ; Pyramidal cells ; Interneurons ; Prefrontal cortex ; Piriform cortex
• 刊名：European Journal of Pharmaceutical Sciences
• 出版年：2008
• 期刊代码：15_09280987
• 类别：pha
• 出版时间：9 June 2008
• 卷：34
• 期：1, Supplement 1
• 页码：S31
• 文件大小：55 K

摘要

Down-regulation of 5-hydroxytryptamine_2A (5-HT_2A) receptors has been a consistent effect induced by most antidepressant drugs. In contrast, electroconvulsive shock (ECS) up-regulates the number of 5-HT_2A receptor binding sites. However, the effects of antidepressants on 5-HT_2A receptor-mediated responses on identified cells of the cerebral cortex have not been examined. The purpose of the present study was to compare the effects of the tricyclic antidepressant imipramine and ECS on 5-HT_2A receptor-mediated electrophysiological responses involving glutamatergic and GABAergic neurotransmission in the rat medial prefrontal cortex (mPFC) and piriform cortex, respectively. The electrophysiological effects of activating 5-HT_2A receptors were consistent with 5-HT_2A receptor binding regulation for imipramine and ECS except for the mPFC where chronic ECS decreased the potency of 5-HT at a 5-HT_2A receptor-mediated response. These findings are consistent with the general hypothesis that chronic antidepressant treatments shift the balance of serotonergic neurotransmission towards inhibitory effects in the cortex.