FDG-PET/CT Imaging for Staging and Target Volume Delineation in Preoperative Conformal Radiotherapy of Rectal Cancer

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• 作者：Maria Chiara Bassi ; Lucia Turri ; Gianmauro Sacchetti ; Gianfranco Loi ; Barbara Cannillo ; Pierdaniele La Mattina ; Marco Brambilla ; Eugenio Inglese ; Marco Krengli
• 关键词：FDG-PET ; Rectal cancer ; Radiotherapy ; Staging ; Treatment planning
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2008
• 期刊代码：136_03603016
• 类别：med
• 出版时间：1 April 2008
• 卷：70
• 期：5
• 页码：1423-1426
• 文件大小：212 K

摘要

A new method for the preparation of β,β-difluoro- (and other gem-difluoro) acids has been developed. It is based on the fact that 3-oxocarboxylic esters are easy to make and convert to the corresponding dithiane derivatives. These dithianes reacted with BrF₃, a commercial, but rarely used reagent in organic chemistry, under very mild conditions to form the corresponding difluoroesters, which in turn could be quantitatively hydrolyzed to the free gem-difluoroacids.