Health outcomes of interest for evaluation in the Post-Licensure Rapid Immunization Safety Monitoring Program

详细信息	查看全文 | 推荐本文 |

• 作者：Tracy A. Lieu^a ; ^b ; ^{tracy_lieu@harvardpilgrim.org} ; ^{tracy_lieu@hphc.org} ; Michael D. Nguyen^c ; Robert Ball^c ; David B. Martin^c
• 关键词：FDA ; food and drug administration ; PRISM ; post-licensure rapid immunization safety monitoring ; HOI ; health outcome of interest
• 刊名：Vaccine
• 出版年：2012
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：16 April, 2012
• 卷：30
• 期：18
• 页码：2824-2830
• 文件大小：225 K

摘要

Active vaccine safety surveillance systems commonly use computerized diagnostic codes to identify potential health outcomes of interest. Evidence concerning the accuracy of these codes is variable, and few systematic reviews are available. This project's aim was to select a list of health outcomes of interest most suitable for evaluation in the Food and Drug Administration's Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program. We conducted an expert elicitation process to develop the list. A comprehensive list of potential health outcomes of interest was formed based on input from a wide variety of vaccine safety experts. We then selected five panelists with senior leadership roles in vaccine safety from both within and outside the FDA. We elicited the experts鈥?recommendations via a structured, iterative process that included an Internet-assisted telephone conference call and formal voting procedures. The expert panelists identified several criteria as important in their choices, including clinical severity, public health importance, rare or uncommon incidence, relevance to two or more vaccines, and historical association with vaccines. The list of 24 outcomes chosen by the experts and refined by the FDA included ten neurologic outcomes, two circulatory system outcomes, and two musculoskeletal outcomes. The PRISM program plans to conduct a set of evidence reviews on the positive predictive value and other characteristics of existing computerized codes and algorithms to identify these health outcomes of interest.