Pathophysiology of bladder dysfunction in Parkinson's disease

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• 作者：Ryuji Sakakibara^a ; ^{sakakibara@sakura.med.toho-u.ac.jp} ; Fuyuki Tateno^a ; Masahiko Kishi^a ; Yohei Tsuyuzaki^a ; Tomoyuki Uchiyama^b ; Tatsuya Yamamoto^b
• 关键词：Parkinson's disease ; Bladder dysfunction ; Dopamine D1 receptors
• 刊名：Neurobiology of Disease
• 出版年：2012
• 期刊代码：80_09699961
• 类别：neu
• 出版时间：June, 2012
• 卷：46
• 期：3
• 页码：565-571
• 文件大小：623 K

摘要

Bladder dysfunction (urinary urgency/frequency) is a common non-motor disorder in Parkinson's disease (PD). In contrast to motor disorders, bladder dysfunction is sometimes non-responsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine basal ganglia-frontal circuit, which normally suppresses the micturition reflex. The pathophysiology of the bladder dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. These treatments might be beneficial in maximizing the patients' quality of life.