Identification and characterisation of high affinity nucleoside and nucleobase transporters in Toxoplasma gondii

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• 作者：De Koning ; Harry P. ; Al-Salabi ; Mohammed I. ; Cohen ; Adrian M. ; Coombs ; Graham H. ; Wastling ; Jonathan M.
• 关键词：Toxoplasma gondii ; Purine salvage ; Nucleobase transporter ; Nucleoside transporter ; Pyrimidine uptake ; Apicomplexan
• 刊名：International Journal for Parasitology
• 出版年：2003
• 期刊代码：124_00207519
• 类别：med
• 出版时间：July 30, 2003
• 卷：33
• 期：8
• 页码：821-831
• 文件大小：395 K

摘要

The protozoan parasite Toxoplasma gondii depends upon salvaging the purines that it requires. We have re-analysed purine transport in T. gondii and identified novel nucleoside and nucleobase transporters. The latter transports hypoxanthine (TgNBT1; K_m