Therapeutic effects of Δ⁹-THC and modafinil in a marmoset Parkinson model

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• 作者：Sanneke A.M. van Vliet ; Raymond A.P. Vanwersch ; Marjan J. Jongsma ; Berend Olivier ; Ingrid H.C.H.M. Philippens
• 关键词：Parkinson's disease ; Therapy ; Modafinil ; Delta-9-tetrahydrocannabinol ; MPTP ; Marmoset ; Behavior ; Hand– ; eye coordination ; Locomotor activity
• 刊名：European Neuropsychopharmacology
• 出版年：2008
• 期刊代码：95_0924977x
• 类别：med
• 出版时间：May 2008
• 卷：18
• 期：5
• 页码：383-389
• 文件大小：339 K

摘要

Current therapies for Parkinson's disease (PD) like mCaps">l-dopa and dopamine (DA) agonists have declined efficacy after long term use. Therefore, research towards supplementary or alternative medication is needed. The implementation in PD can be expedited by application of compounds already used in the clinic. In this study the therapeutic effects of the psychoactive compounds Δ⁹-tetrahydrocannabinol (Δ⁹-THC) and modafinil were tested in the 1-methyl-1,2,3,6-tetrahydropyridine (MPTP)–marmoset model for PD.