Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

详细信息	查看全文 | 推荐本文 |

• 作者：Santosh N. Mokale^a ; Deepak Lokwani^b ; Devanand B. Shinde^b ; ^{dbssantosh06@rediffmail.com}
• 关键词：Reverse transcriptase inhibitors ; Docking ; NNRTIs ; HIV-1
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2012
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：1 May, 2012
• 卷：20
• 期：9
• 页码：3119-3127
• 文件大小：4583 K

摘要

A novel series of substituted imidazol-5-ones were designed, synthesized and evaluated for in vitro reverse transcriptase (RT) inhibition activity using reverse transcriptase assay kit (Roche, Colorimetric). It has been observed from in vitro screening that newly synthesized compounds possess RT inhibitory activity. Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.